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DET
Detroit Lions @ Buffalo Bills
BUF

Thursday, September 17 at 8:17 PM EDT

FinalDET 31 ยท BUF 41Lines below are the pre-kickoff close.

DET

+5.5

+195

Total

54.5

BUF

-5.5

-238

How games at these numbers have gone

  • The key number. 5.5 sits half a point short of 6, one of the margins games actually land on. That hook is most of what you are paying for or getting here.
  • Spread 5.5 โ€” the 4-6 point band. In 1,063 games since 1999 the favorite covered 49.2% of the time โ€” a coin flip once the 95% range (46.2โ€“52.2%) is taken into account.
  • Total 54.5 โ€” spread in the 3-7 point band. Games with a spread this size went over 49.5% of the time across 3,584 of them.

Last three seasons

DET

21-17-2 ATS ยท 27-13 SU ยท 25-14 O/U

went over in 25 of 39

BUF

25-19 ATS ยท 32-12 SU ยท 27-16 O/U

went over in 27 of 43

Measured on 7,276 games with a closing line and a final score. Records cover three seasons and describe the team โ€” they are not a signal, and every situational split we measured lands at a coin flip. Context, not a pick โ€” see every band.

The Read

Buffalo Bills open a 5.5-point favorite over Detroit Lions โ€” about 70% implied to win outright. The 54.5 total prices it near 30โ€“25, one of the week's higher totals.

Detroit Lions went 9โ€“8 in 2025 โ€” #10 of 32 by point differential (+4.0/g).

Buffalo Bills went 12โ€“5 in 2025 โ€” #6 of 32 by point differential (+6.8/g).

Detroit Lions drew one of the softest 2026 slates (strength of schedule #27).

2025 team profiles

Detroit Lions

2025 record9-8Point diff / game+4.0Pythag wins (rank)10.0 (#10)2026 SOS rank#27

Buffalo Bills

2025 record12-5Point diff / game+6.8Pythag wins (rank)11.2 (#6)2026 SOS rank#8